Recent advancements in cutting technologies like laser, waterjet, wire EDM, and plasma cutting have provided an opportunity to manufacture complex shapes of structural steel sections with minimum tolerances as low as 0.01 mm. Hence, the primary objective of the ARISE project is to take advantage of these advancements to investigate and validate a newly proposed connection system, i.e., Intermeshed Steel Connections (ISCs), having tooth flanges connected through side plates. This system minimizes bolting and welding of connections, facilitates faster erection and reduces labor while it will also help facilitate greater use of digitization and robotic assembly in the steel construction industry. The ongoing research studies have proved the high potential for application of ISCs by the construction industry, but still, a deeper understanding of their structural mechanics is required. The strength of an ISC connection is greatly affected by stress concentrations and other design parameters, hence, this study investigates the effects of these parameters, with the aim of proposing design guidelines for the ISCs. Furthermore, a comparison between manual calculations and numerical models has been carried out to validate the findings. Results are presented from the preliminary computational modelling of connections used in column-column and beam-column joints considering different loading configurations. Finite elements models developed using Abaqus support future research on improved contact performance and load distributions.