Most existing reinforced concrete multi-span bridges designed and constructed using outdated seismic design provisions are highly susceptible to various damage modes when subjected to strong earthquakes. Such bridges require effective retrofitting to enhance their seismic resistance. Therefore, a comprehensive retrofitting approach integrating multiple retrofit measures is essential to address all structural deficiencies effectively. This study proposes the integration of steel dampers and braces to reduce excessive bridge bearing displacement and column curvature ductility demands. The numerical idealization approaches of the chosen seismic risk mitigation measures are verified by comparing their dynamic responses with existing test results, followed by implementing the validated retrofit techniques in a benchmark bridge. Assessment of the lateral load-carrying capacity of the representative bridge before and after retrofitting indicated that the adopted strategy improved the lateral strength by 50%. Furthermore, incremental time history analysis was performed on the retrofitted bridge with integrated retrofit measures under a diverse range of earthquake records. The derived fragility relations demonstrated that the combined retrofit strategy significantly reduced various seismic demands of the existing benchmark structure. This research highlights the advantages of integrating multiple retrofit techniques to mitigate the seismic risk of deficient bridges and maintain their serviceability after earthquakes.