Cement production is a crucial factor responsible for climate change and recognized as major environmental challenge for humankind. It causes around 5% of global CO2 emissions resulting in lowering of air quality and human health. Production of cement is highly energy intensive process requiring consumption of depleting limited natural resources. Granite stone is famous for strength, elegance and durability. Enormous quantity of granite slurry waste is generated during processing of granite stone blocks, which adversely affect the fertility of land, environment and society. Metakaolin is an ultrafine pozzolonic and economical alternative to silica fume. It has positive influence on concrete properties because of filling effect and additional pozzolanic reaction. In this experimental investigation replacement level of both granite slurry waste and metakaolin are taken up to 10% as partial replacement of cement. Mechanical and durability properties of modified concrete have been evaluated. It has been shown that optimum replacement level of both materials enhances the compressive and flexural strength. Also, improvement in water permeability and resistance to acid attack has been observed. This study demonstrates that utilization of granite slurry waste and metakaolin as partial replacement of cement will reduce the consumption of cement, which will conserve the natural resource, reduces CO2 emission, energy demand and waste accumulation. Hence, the production of new composite concrete will be sustainable and advantageous to the environment and society.