Improving water supply infrastructure in rural areas is crucial to achieving Sustainable Development Goal 6 (SDG6), which aims for universal access to safe drinking water and sanitation. Water supply systems in rural communities in Honduras face unique challenges, including geographic isolation, limited infrastructure, and financial constraints, which have hindered their progress. Currently, in Honduras, Polyvinyl Chloride (PVC) pipes are used to design and construct drinking water supply systems; however, new materials and construction techniques must be employed in water supply projects to enhance the coverage and quality of water services in rural areas and meet SDG6. Thus, the primary focus of this study was to determine whether implementation of High-Density Polyethylene (HDPE) pipes in drinking water conveyance systems is feasible and viable. Velocities, pressures, optimal diameters, and losses were determined using EPANET for both PVC and HDPE pipes, with no significant differences observed. Regarding costs, HDPE pipes are 8.92% cheaper in CAPEX and 6% in OPEX compared to PVC pipes. Additionally, execution times are shorter for HDPE pipes due to their more straightforward installation process compared to PVC. The results indicate that incorporating HDPE pipes into drinking water conveyance systems in rural areas of Honduras is both viable and feasible. This finding is significant as it has potential to improve water supply situation in Honduras, particularly in rural areas, and contribute to achieving the SDGs.