In order to analyze the impacts of pre-stress loss on the long-term deflection for long-span PC continuous girder bridges, this paper presents a numerical analysis using the finite element analysis software MIDAS/Civil based on a long-span PC continuous box-section girder bridge in Shijiazhuang. Once the 3-D finite element model was established, the influences of different pre-stress loss levels and locations were analyzed in a numerical simulation. Pre-stress loss is often the key reason for long-term deflection in long-span PC continuous girder bridges, so we can estimate the development of deflection by considering these factors during the operation.