Applying Virtual Reality (VR) in construction professional training has been advocated as an effective method to improve learner’s cognition. However, there has been a lack of a systematic approach in VR-based training in the construction context. This study aims to develop a framework to institutionalize VR-based construction professional training design. Virtual Generation and Experience Road Map (VGERM) was adopted in the development of the mobile VR app for use in teaching substructure in an undergraduate construction technology course. A mobile VR app was developed by using a Unity-based platform, namely EduVenture. Procedures of the VR app development were articulated with an aim to demonstrate how the proposed framework can be utilized in fostering knowledge and skills transfer. Feedback of the users was collected through the Course Experience Survey. Findings of this study help gain a better understanding of the key areas to foster the benefits of VR for efficient use within professional construction training.