The post-earthquake reconstruction should solve the problem to rebuild with safety but preserving the historical aspect of buildings and landscapes. This paper proposes a particular application of seismic isolation for the reconstruction of entire urban quarter or entire small centers with integral seismic protection. This involves the construction of large floating slabs having the size of entire compartments supported by seismic isolators and/or dampers, above which to construct buildings that can present the aesthetic and constructive characteristics of the collapsed traditional ones. The solution is suited for the reconstruction of villages or quarters collapsed or damaged. Buildings of any type (masonry, stone, r/c, steel, wood) and of different characteristics also significantly irregular can be freely built above slabs and all of them will be fully protected from the consequences of future expected quakes. Paper illustrates a case study related to a quarter of a historic town in Central Italy.