We report the progress of our research on understanding the seismic performance of frames with uneven large section beams and clarify the influence of the height of beams and the shape of fitting type joints on the behavior of the frame. In this study, we conducted a cyclic loading test for four test frames with spans of one or two and investigated the seismic performance and failure behavior. The major findings for the two-span frames are summarized as follows. (a) They caused fatal damage more readily than the one-span frames. The column that was caught in the even beams broke before other damage occurred. (b) Because of the asymmetry of the frame or the shape of the column-beam joints, the shear forces had directional dependence.