The paper presents a numerical research on the behavior of steel I-beams with web openings. The influence of web openings in the load carrying capacity of steel beams and failure mechanisms are investigated. The non-linear numerical analysis performed was calibrated with results from other similar non-linear numerical analysis and experimental test data. Comparison between numerical results with the available experimental for yielding patterns, ultimate load values and load-deflection relationships show a good agreement. The numerical model developed was used to carry out a parametric study taking into account some parameters, such us: opening shape, opening size, and the location of the opening throughout the span. Three different beam spans were considered. A contribution to the analysis and selection of the web openings best solutions is presented in the conclusions.