Portland cement (PC) is used in the production of Portland cement concrete (PCC) to construct many infrastructure components such as rigid pavements. This research aims at studying the effect of using common waste materials in Egypt as a replacement of PC in the production of PCC. Using waste materials in concrete production could be an effective measure in maintaining the environment, improving the properties of PCC, and reducing cost of production. Nowadays, pavement technologist and researchers had put their interests on nanotechnology. This paper outlines the innovation of using Nanotechnology-based waste materials as a replacement of PC to enhance the physical and mechanical properties of PCC. The experimental work, using waste materials such as ceramic waste (CW) and ground-granulated blast-furnace slag (GGBFS), was conducted in five phases. In phase 1 and phase 2, different rations were used for CW and GGBFS by weight of cement, respectively. In phase 3, the best three ratios of CW were used with the best ratio of GGBFS. In phase 4, different ratios of CW and GGBFS were used with a standard ratio of Un-Hydrated lime (UHL). In phase-5, various mix of CW, GGBFS and UHL were suggested based on previous results. Modified PCC mixtures were produced, tested and compared to the conventional concrete mixture. Results showed that the cost of PCC production is reduced by 34% in average comparing to the control mix.