When considering the maintenance of buildings, the implementation of legislative codes for health and safety requires particular attention as early as in the design approach. Statistics indicate that accidents often occur during maintenance operations. The organization of the maintenance yard requires specific safety measures, which often depend on the choices related to the design and construction of a building. European Directive 57/1992 indicates that “the architectural and/or organizational measures are not enough. A poor design frequently causes work-related accidents in construction sites with significant damage to the community.” This statement, dating back 22 years, is still valid in Europe today. The introduction of the obligation to draw up the Safety File, to manage safety in the maintenance tasks of the building life cycle, is still valid. This paper refers to the maintenance tasks programmed by ensuring safety conditions. Particular focus is on the individuation of the types of risks in relation to design. The design choices, likewise, are made in order to have an effective plan of health and safety for the workers. The preventive identification of the most common natural risks, and the application of practice codes related to maintenance programs, are the most important strategic choices to ensure safety in interventions deferred over time.