This paper provides a methodological definition and the first setting of a BIM-enabled Facility Management approach for building stocks, to be applied to O&M contracts, based on Post-Occupancy Evaluation (POE) methods. The use of BIM, combined with advanced monitoring techniques, facilitates the development of effective decision- making approaches for the operational stage of the building Life Cycle. Information obtained through POEs performed on real-time data can converge in the BIM model - and related database- of the building, to be used as a data repository and as the base for future scenarios analyses, simulating potential optimizations in facility management. This approach is being applied and tested in a case study building. This work is developed by analyzing current FM techniques, followed by the installation of sensors and cameras in the case study building, monitoring current usage patterns. Post Occupancy Evaluation analyses are then carried out to define an updated and more efficient FM scenario. Further developments in this sense regard the development of a mobile application providing permanent monitoring of the O&M conditions and the setting of Smart Contracts for FM. This approach could facilitate optimization of space use, an increase in quality of O&M activities, and optimization of the contractual aspects of facility management.