This paper is aimed to develop a design procedure of Polynomial Friction Pendulum Isolator (PFPI), a various-frequency sliding isolator, for decreasing the seismic responses of isolated bridges. Although sliding isolators have been widely used to mitigate seismic hazard, it may be not effective in decreasing the seismic responses of isolated structures subjected to near-field ground motions. The sliding surface of the PFPI is defined by a sixth-order polynomial function to avoid resonance under near-field ground motions. The restoring stiffness of the PFPI possesses softening section as well as hardening section. The structural acceleration response can be decreased by decreasing the restoring stiffness in softening section while the structural displacement response can be decreased by increasing the restoring stiffness in hardening section. However, it is difficult to determine the design parameters of PFPI in practical implementations. This study proposes a design procedure for the PFPI based on the bridge seismic design code in Taiwan. Designers can follow this procedure to easily design the bridge with PFPIs which satisfies the requirements of the code. The bridge with PFPIs designed by using this procedure is analyzed to realize the dynamic nonlinear responses of the bridge under artificial strong earthquake. The results show that the PFPIs effectively decrease the seismic responses of isolated bridges as compared with non-isolated bridges.